Trader Lab Associations:
-Department of Pharmaceutical Sciences -UCI Cancer Institute- Drug Development and Chemical Biology Faculty |
PI: Darci J. TraderDarci received her BS and MS in chemistry from Southern Illinois University-Edwardsville in 2006 and 2007, respectively. She then went on to pursue her doctoral studies at Indiana University under the direction of Prof. Erin E. Carlson. Here, she worked on developing a new chemoselective enrichment tagging protocol to discover natural products. After obtaining her PhD in 2013, she joined The Scripps Research Institute in Prof. Tom Kodadek's lab. At TSRI she learned to generate HTS libraries and screen them for the desired biological activity. Her own lab is focused the development of drug-like molecules and probes to monitor and perturb the activity of the proteasome. Small molecule probes, stimulators, and inhibitors are being generated to study the role of the standard proteasome and immunoproteasome in a variety of diseases. Her trainees are currently pursuing medicinal chemistry and chemical biology studies to develop new treatments for hematological cancers, proteasome stimulators to combat neurological diseases associated with protein accumulation, and new techniques to target the activity of the immunoproteasome.
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Spring 2024
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Trader Laboratory PersonNel
KAte Kragness |
Duno Dantis |
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Pharm Sci graduate student |
Chemistry graduate student |
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B.S. Purdue University, Biochemistry
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B.S. University of the Philippines-Diliman, Chemistry
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Cody Loy |
Tim Harris |
Pharm Sci Graduate StudentB.S. Ball State, Chemistry
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Pharm Sci Graduate StudentB.S. Rose-Hulman Institute of Technology, Biochemistry
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Robert Zepeda |
Jaida Osman |
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Pharm Sci graduate student |
Chemistry Graduate student |
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B.S. UC Riverside, Chemistry
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B.S. Cal State San Marcos, Biochemistry
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Alumni
Postdocs
Dr. Eslam Ali- University of Virginia Drug Discovery Core
Dr. Breanna Zerfas- Dana Farber, Research Scientist
Graduate Students
Dr. Andres Salazar-Chaparro (Ph.D.) 2023- Postdoc at Dana Farber
Dr. Christine Muli (Ph.D.) 2022- Postdoc at NIH-NCI
Dr. Marianne Maresh (Ph.D.) 2021- Postdoc at the University of Michigan
Dr. Wenzhi Tian (Ph.D.) 2021- Postdoc at the Broad Institute
Dr. Rachel Coleman (Ph.D.) 2020- Postdoc at UAB
Undergraduates
Nathan Macatangay (Undergraduate)- PharmD Student at Purdue
Brant Hoggatt (Undergraduate)
Brice Wuthrich (Undergraduate)- IU School of Medicine
Dr. Eslam Ali- University of Virginia Drug Discovery Core
Dr. Breanna Zerfas- Dana Farber, Research Scientist
Graduate Students
Dr. Andres Salazar-Chaparro (Ph.D.) 2023- Postdoc at Dana Farber
Dr. Christine Muli (Ph.D.) 2022- Postdoc at NIH-NCI
Dr. Marianne Maresh (Ph.D.) 2021- Postdoc at the University of Michigan
Dr. Wenzhi Tian (Ph.D.) 2021- Postdoc at the Broad Institute
Dr. Rachel Coleman (Ph.D.) 2020- Postdoc at UAB
Undergraduates
Nathan Macatangay (Undergraduate)- PharmD Student at Purdue
Brant Hoggatt (Undergraduate)
Brice Wuthrich (Undergraduate)- IU School of Medicine